First let’s understand proteases:
Protease is a specific aspartyl protease in the gene code of the human immunodeficiency virus that serves to cleave genes and proteins resulting from gene expression into active viral structural proteins and enzymes.
What are protease inhibitors?
Protease inhibitor, foreign name (protease inhibitor), peptide compound.
are peptide-based compounds that either competitively inhibit protease activity or act as inhibitors of complementary protease active sites.
Protease inhibitors are new in the mid to late 1990s, and the drug synthesis process is difficult.
How do protease inhibitors work?
Trypsin works by hydrolyzing intercellular proteins and thereby causing cells to dissociate. Different tissues or cells respond differently to the action of trypsin.
Protease inhibitors bind to the catalytic gene of the viral protease to inhibit the enzyme activity, resulting in the inability to cleave the protein precursor and form a mature virion.
