Explain specific applications of protease inhibitors in medicine
Specific applications of protease inhibitors in medicine include treatment of HIV infection, acute pancreatitis, hemorrhage due to fibrinolysis, diffuse intravascular coagulation, antishock therapy, pneumothorax, traumatic injury, pyothorax and other diseases.
Treatment of HIV infection: protease inhibitors are an important component of anti-HIV drug combination therapy, which prevents viral replication by inhibiting protease activity, thereby reducing inflammatory response and promoting wound healing to Achieve anti-inflammatory purpose.
Acute Pancreatitis: Peptidase is a protease inhibitor that inhibits trypsin and chymotrypsin and prevents the activation of other active proteasogens in the pancreas as well as the self-activation of trypsinogen. It is used clinically for the prevention and treatment of acute pancreatitis, fibrinolysis-induced bleeding and diffuse intravascular coagulation. It is also used in anti-shock therapy.
Other diseases: protease inhibitors have a broader role and are commonly used in the treatment of pneumothorax, traumatic injuries, and pyothorax. Patients who are allergic to protease inhibitors are not allowed to use them. Patients who are allergic to this drug may experience breathing difficulties or even shock.
It has the effect of inhibiting the activity of various pancreatic enzymes such as trypsin and is commonly used in the treatment of pancreatitis. In addition, it can stabilize the lysosomal membrane, inhibit the release of lysosomal enzymes, and inhibit the production of myocardial inhibitory factor, and so on, so it can be used in the rescue treatment of acute circulatory failure. 4.
In addition, it can stabilize lysosomal membrane, inhibit the release of lysosomal enzymes and inhibit the production of myocardial inhibitory factor, so it can be used in the rescue treatment of acute circulatory failure.
In summary, protease inhibitors are widely used in the field of medicine, not only play an important role in antiviral therapy, but also in the prevention and treatment of acute pancreatitis and other diseases have shown remarkable results.
